30 Best Southern American Restaurants In Medical Centre

30 restaurants available nearby

How are Featured results ranked

A photo of Southerleigh Haute South restaurant

1. Southerleigh Haute South

4.3

Awesome(712)

€€€€

• Southern • Northwest

Booked 8 times today

Great job! Never disappoints. Great food! Will continue to go back!

A photo of Ida Claire - San Antonio restaurant

2. Ida Claire - San Antonio

4.6

Exceptional(3022)

€€€€

• Southern • Alamo Heights

Booked 65 times today

A new San Antonio favorite for us! Great place. 🙏🙏

A photo of Meadow Neighborhood Eatery + Bar restaurant

3. Meadow Neighborhood Eatery + Bar

4.8

Exceptional(1002)

€€€€

• Southern • North Central

Booked 13 times today

Always wonderful! Michael and team took the best care of us and food and drinks were amazing!

A photo of Southerleigh Fine Food & Brewery restaurant

Icon

4. Southerleigh Fine Food & Brewery

4.7

Exceptional(3442)

€€€€

• Southern • Downtown

Booked 30 times today

First time dining, came because of their3 year Michelin recognized. We ordered what came recommended from other reviews and were NOT disappointed. Deviled eggs, snapper and pressure cooked fried chicken were all amazing. Laurence provided great service and very knowledgable, has been there for years. Southerleigh is now one of our top dining choices.

5. NOLA Restaurant

4.5

Awesome(252)

€€€€

• Southern • Downtown

Booked 33 times today

Nola is a great place for a business meeting, and I love the hint of chicory in their signature coffee. The praline bacon that is served with the brunch plate is unusual and flavorful, and definitely a treat!

A photo of Domingo Restaurante restaurant

6. Domingo Restaurante

4.4

Awesome(1410)

€€€€

• Southern • Downtown

Booked 62 times today

Absolutely amazing experience! I’ve been to the Riverwalk in San Antonio several times. I don’t know how I haven’t been to this restaurant yet, but it is by far the best restaurant in the area. My wife and I had dinner here and tried the Hatch Queso with Chorizo, Beef Taquitos, Shrimp Tacos and Green Chili & Chicken Enchiladas. Everything was delicious. Personally, I enjoyed the Shrimp Tacos and Hatch Queso the most. The atmosphere is fantastic and there are great views right by the water. The service is phenomenal. I couldn’t have asked for more. I’m excited to return again and try more items on their food menu!

A photo of The Hayden - Broadway restaurant

7. The Hayden - Broadway

4.7

Exceptional(124)

€€€€

• Southern • Alamo Heights

Booked 28 times today

The Hayden is one of our go-to restaurants. The food and drinks are always excellent, but the prices are lower than you would expect, which makes them even better. Our favorites include the barbacoa stroganoff and the fish and chips, but we have never had a bad meal there. The service is friendly and competent. I promise you will love it too.

A photo of Four Brothers Southern Provisions restaurant

8. Four Brothers Southern Provisions

4.6

Exceptional(615)

€€€€

• Southern • Downtown

Booked 17 times today

My hubby & I had a delicious brunch yesterday. We highly recommend the Smoked Salmon Croissant, All American Breakfast, & Avacado Toast. Our waiter, Filberto, was exemplimary. He went above & beyond of our dining needs. The ambiance of the dining room is elegant & tastefully designed with a view to the San Antonio Riverwalk. This was the perfect first impression to our first day & first time in San Antonio. Thank You.

A photo of Boiler House at Pearl restaurant

9. Boiler House at Pearl

4.3

Awesome(2279)

€€€€

• Southern • Downtown

Booked 10 times today

What a great time! The restaurant is beautiful & comfortable. The food was good, but surprisingly the side dishes were what really shined 👀 We ordered one of each for the table & couldn’t get enough 😂 The staff was absolutely incredible from the second we walked in. So friendly and inviting. Definitely a place we will return to!

10. Mama's Cafe

4.7

Exceptional(579)

€€€€

• Southern • Alamo Heights

Booked 40 times today

As always, Mama's had great comfort food. Service was fast and friendly, and the variety of options on the menu means there is something for everyone.

Best Southern American Restaurants in Medical Centre

Price

Regions

Areas

Top Rated

Dining Options

Seating options

Award-winning

Accessibility

30 restaurants available nearby

1. Southerleigh Haute South

2. Ida Claire - San Antonio

3. Meadow Neighborhood Eatery + Bar

4. Southerleigh Fine Food & Brewery

5. NOLA Restaurant

6. Domingo Restaurante

7. The Hayden - Broadway

8. Four Brothers Southern Provisions

9. Boiler House at Pearl

10. Mama's Cafe

See what locals rave about

Explore OpenTable